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The Association of American Universities (AAU) and the Association of Public and Land-grant Universities (APLU) have collaborated and led national discussions to improve public access to data resulting from federally funded research. As part of the NSF-funded (NSF # 1939279) Accelerating Public Access to Research Data Initiative, AAU and APLU convened representatives from the university teams at an Acceleration Conference in 2020 and facilitated two national Summits to help universities create robust systems for ensuring effective public access to high-quality research data and develop the current Guide. The Guide has been informed by 261 campus representatives from 111 institutions, representatives from several federal agencies, and other key stakeholders. The Guide is designed to help institutions develop and promote systems to support sharing of research data. It provides advice concerning actions that can be taken to improve access to research data on campuses. It also contains information about the infrastructure and support that may be required to facilitate data access, and it offers specific examples of how various institutions are approaching challenges to sharing research data and results.